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Tohoku Univ. Technology : Improvement of Filamentous Fungi Using TAQing System : T22-154

Tohoku Univ. Technology : Improvement of Filamentous Fungi Using TAQing System : T22-154

Production of secondary metabolites derived from fungal dormancy genes

Many drugs have been developed from natural products produced by filamentous fungi. On the other hand, it has been reported that many biosynthetic genes of unexplored natural products that can be candidates for drugs are dormant on the genome of filamentous fungi. Using a large-scale genome rearrangement technology "TAQing system (A technique in which the restriction enzyme TAQI is introduced into a cell to simultaneously and multiply break DNA double strands, followed by recombination repair to produce a variety of genomic rearrangements)," the inventors generated a number of mutant strains of filamentous fungi in which dormant biosynthetic genes were activated, and succeeded in remarkably inducing the production of natural products not produced by wild strains. 　The development of a secondary metabolic activation method using the TAQing system has been investigated using the model filamentous fungus Aspergillus nidulans.

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New genome editing technology "CRISPR-Cas3 system"

New genome editing technology "CRISPR-Cas3 system"

About the new genome editing technology 'CRISPR-Cas3'

CRISPR-Cas3 is a genome editing technology developed in Japan based on the research results of Professor Tomoshige Mukaida from the Advanced Animal Genome Research Division at the University of Tokyo Institute of Medical Science, and Professor Junji Takeda from the Osaka University Graduate School of Microbiology. CRISPR-Cas3 has the characteristic of inducing large deletions by continuously cutting the genome, and it also has a very low impact from off-target effects. Recently, Nippon Gene Co., Ltd. has entered into a licensing agreement with C4U Co., Ltd. regarding CRISPR-Cas3 technology and has begun supplying high-purity Cas3 protein and Cascade-crRNA complexes. 【Features of the CRISPR-Cas3 System】 - Large-scale deletions of the genome are possible - Low risk of off-target mutations and high specificity (a highly safe genome editing technology) - Simple licensing makes it easier to establish strategies for the practical application of genome editing technology *For more details, please refer to the catalog.

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[Research Material] The Global Market for Gene Editing

[Research Material] The Global Market for Gene Editing

Global Market for Gene Editing: Zinc Finger Nucleases (ZFN), Transcription Activator-Like Effector-Based Nucleases (TALE ...

This research report (Global Gene Editing Market) investigates and analyzes the current state of the global gene editing market and its outlook for the next five years. It includes information on the overview of the global gene editing market, trends of major companies (sales, selling prices, market share), market size by segment, market size by major regions, and distribution channel analysis. The segments by type in the gene editing market focus on Zinc Finger Nucleases (ZFN), Transcription Activator-Like Effector Nucleases (TALEN), and CRISPR-Cas systems, while the segments by application target biotechnology and pharmaceutical companies, academic and government research institutions, and contract research organizations. The regional segments calculate the market size for gene editing divided into North America, the United States, Europe, Asia-Pacific, Japan, China, India, South Korea, Southeast Asia, South America, the Middle East, and Africa. It also includes the market share of major companies in gene editing, product and business overviews, and sales performance.

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